Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prox1  prospero homeobox 1   (Synonyms: A230003G05Rik)
Results	Reference
1*	J:205268 Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J, Pitx3 directly regulates Foxe3 during early lens development. Int J Dev Biol. 2013;57(9-10):741-51
1	J:186594 Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S, CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. Circ Res. 2011 Aug 19;109(5):486-91
1*	J:206581 Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, Francois M, Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 1;386(1):25-33
1*	J:136688 Buttler K, Ezaki T, Wilting J, Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics. BMC Dev Biol. 2008;8:43
1*	J:108556 Buttler K, Kreysing A, von Kaisenberg CS, Schweigerer L, Gale N, Papoutsi M, Wilting J, Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos. Dev Dyn. 2006 Jun;235(6):1554-1562
1	J:333725 Chiang IKN, Graus MS, Kirschnick N, Davidson T, Luu W, Harwood R, Jiang K, Li B, Wong YY, Moustaqil M, Lesieur E, Skoczylas R, Kouskoff V, Kazenwadel J, Arriola-Martinez L, Sierecki E, Gambin Y, Alitalo K, Kiefer F, Harvey NL, Francois M, The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO J. 2023 Mar 1;42(5):e109032
1	J:289355 Cho H, Kim J, Ahn JH, Hong YK, Makinen T, Lim DS, Koh GY, YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis. Circ Res. 2019 Jan 18;124(2):225-242
1	J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
1	J:211805 Coxam B, Sabine A, Bower NI, Smith KA, Pichol-Thievend C, Skoczylas R, Astin JW, Frampton E, Jaquet M, Crosier PS, Parton RG, Harvey NL, Petrova TV, Schulte-Merker S, Francois M, Hogan BM, Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep. 2014 May 8;7(3):623-33
1	J:154975 D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V, Hodivala-Dilke KM, Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development. 2009 Dec;136(23):4043-53
1*	J:145843 Duncan MK, Cui W, Oh DJ, Tomarev SI, Prox1 is differentially localized during lens development. Mech Dev. 2002 Mar;112(1-2):195-8
1*	J:183953 Francois M, Short K, Secker GA, Combes A, Schwarz Q, Davidson TL, Smyth I, Hong YK, Harvey NL, Koopman P, Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol. 2012 Apr 15;364(2):89-98
1	J:228882 Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MK, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS, Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016 Jan 1;409(1):218-33
1	J:243226 Geraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S, GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017 Mar 01;127(3):1099-1114
1	J:261727 Gil HJ, Ma W, Oliver G, A novel podoplanin-GFPCre mouse strain for gene deletion in lymphatic endothelial cells. Genesis. 2018 Apr;56(4):e23102
1*	J:137168 Gordon EJ, Gale NW, Harvey NL, Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn. 2008 Jul;237(7):1901-9
1*	J:266923 Grifone R, Saquet A, Xu Z, Shi DL, Expression patterns of Rbm24 in lens, nasal epithelium, and inner ear during mouse embryonic development. Dev Dyn. 2018 Oct;247(10):1160-1169
1	J:117093 Gui H, Li S, Matise MP, A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol. 2007 Jan 1;301(1):14-26
1	J:194396 Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F, A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013 Feb 12;32(5):629-44
1*	J:135686 Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T, Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008 Apr 1;316(1):149-59
1	J:264574 Jacob A, Wust HM, Thalhammer JM, Frob F, Kuspert M, Reiprich S, Balta EA, Lie DC, Wegner M, Sock E, The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis. J Neurochem. 2018 Aug;146(3):251-268
1	J:218198 Kaltezioti V, Antoniou D, Stergiopoulos A, Rozani I, Rohrer H, Politis PK, Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons. J Neurosci. 2014 Nov 19;34(47):15816-31
1	J:225799 Kazenwadel J, Betterman KL, Chong CE, Stokes PH, Lee YK, Secker GA, Agalarov Y, Demir CS, Lawrence DM, Sutton DL, Tabruyn SP, Miura N, Salminen M, Petrova TV, Matthews JM, Hahn CN, Scott HS, Harvey NL, GATA2 is required for lymphatic vessel valve development and maintenance. J Clin Invest. 2015 Aug 3;125(8):2979-94
1	J:185540 Keenan ID, Rhee HJ, Chaudhry B, Henderson DJ, Origin of non-cardiac endothelial cells from an Isl1+ lineage. FEBS Lett. 2012 Jun 21;586(13):1790-4
1*	J:121242 Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim KC, Engel JD, A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development. 2007 May;134(9):1703-12
1	J:214795 Klein KR, Karpinich NO, Espenschied ST, Willcockson HH, Dunworth WP, Hoopes SL, Kushner EJ, Bautch VL, Caron KM, Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014 Sep 8;30(5):528-40
1	J:121794 Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z, Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis. 2007 Apr;45(4):157-68
1*	J:149253 Kulkarni RM, Greenberg JM, Akeson AL, NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65
1	J:170175 Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL, Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40
1	J:181272 Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL, Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar;241(3):493-504
1	J:145450 Lee S, Kang J, Yoo J, Ganesan SK, Cook SC, Aguilar B, Ramu S, Lee J, Hong YK, Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood. 2009 Feb 19;113(8):1856-9
1	J:266590 Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, Cleaver O, Oliver G, Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions. Development. 2018 Aug 20;145(17):dev165092
1	J:316476 Ma W, Gil HJ, Liu X, Diebold LP, Morgan MA, Oxendine-Burns MJ, Gao P, Chandel NS, Oliver G, Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance. Sci Adv. 2021 Apr;7(18)
1	J:249824 Martinez-Corral I, Ulvmar MH, Stanczuk L, Tatin F, Kizhatil K, John SW, Alitalo K, Ortega S, Makinen T, Nonvenous origin of dermal lymphatic vasculature. Circ Res. 2015 May 8;116(10):1649-54
1	J:305417 Martucciello S, Turturo MG, Bilio M, Cioffi S, Chen L, Baldini A, Illingworth E, A dual role for Tbx1 in cardiac lymphangiogenesis through genetic interaction with Vegfr3. FASEB J. 2020 Nov;34(11):15062-15079
1	J:329978 Maruyama K, Miyagawa-Tomita S, Haneda Y, Kida M, Matsuzaki F, Imanaka-Yoshida K, Kurihara H, The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse. Elife. 2022 Oct 5;11:e81515
1*	J:278916 Maruyama K, Miyagawa-Tomita S, Mizukami K, Matsuzaki F, Kurihara H, Isl1-expressing non-venous cell lineage contributes to cardiac lymphatic vessel development. Dev Biol. 2019 Aug 15;452(2):134-143
1	J:109351 Miller LA, Smith AN, Taketo MM, Lang RA, Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol. 2006;6:14
1	J:294364 Moon EH, Kim YH, Vu PN, Yoo H, Hong K, Lee YJ, Oh SP, TMEM100 is a key factor for specification of lymphatic endothelial progenitors. Angiogenesis. 2020 Aug;23(3):339-355
1	J:211806 Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, Germino GG, Watnick T, Polycystin signaling is required for directed endothelial cell migration and lymphatic development. Cell Rep. 2014 May 8;7(3):634-44
1	J:282057 Pawlak JB, Balint L, Lim L, Ma W, Davis RB, Benyo Z, Soares MJ, Oliver G, Kahn ML, Jakus Z, Caron KM, Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. J Clin Invest. 2019 Nov 1;129(11):4912-4921
1	J:181761 Planas-Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E, Mechanoinduction of lymph vessel expansion. EMBO J. 2012 Feb 15;31(4):788-804
1	J:158668 Qu X, Tompkins K, Batts LE, Puri M, Baldwin S, Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice. Development. 2010 Apr;137(8):1285-95
1*	J:119144 Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T, The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol. 2006 Jun 15;294(2):458-70
1*	J:145448 Shimoda H, Immunohistochemical demonstration of Angiopoietin-2 in lymphatic vascular development. Histochem Cell Biol. 2009 Feb;131(2):231-8
1	J:111764 Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK, Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006 Feb;17(2):576-84
1	J:101264 Smith AN, Miller LA, Song N, Taketo MM, Lang RA, The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol. 2005 Sep 15;285(2):477-89
1*	J:217439 Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G, The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014 Oct 1;28(19):2175-87
1	J:158959 Srinivasan RS, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, Porto MP, Lagutin O, Oliver G, The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 2010 Apr 1;24(7):696-707
1	J:177488 Srinivasan RS, Oliver G, Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011 Oct 15;25(20):2187-97
1	J:216104 Sugiyama T, Osumi N, Katsuyama Y, A novel cell migratory zone in the developing hippocampal formation. J Comp Neurol. 2014 Oct 15;522(15):3520-38
1	J:204680 Sugiyama Y, Shelley EJ, Wen L, Stump RJ, Shimono A, Lovicu FJ, McAvoy JW, Sfrp1 and Sfrp2 are not involved in Wnt/beta-catenin signal silencing during lens induction but are required for maintenance of Wnt/beta-catenin signaling in lens epithelial cells. Dev Biol. 2013 Dec 15;384(2):181-93
1*	J:262369 Taya Y, Sato K, Shirako Y, Soeno Y, Migration of lymphatic endothelial cells and lymphatic vascular development in the craniofacial region of embryonic mice. Int J Dev Biol. 2018;62(4-5):293-301
1	J:237527 Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S, Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 01;143(21):3994-4002
1*	J:226501 Uchida Y, James JM, Suto F, Mukouyama YS, Class 3 semaphorins negatively regulate dermal lymphatic network formation. Biol Open. 2015;4(9):1194-205
1	J:269956 Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y, Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS One. 2014;9(10):e111432
1*	J:175398 Wei TC, Lin HY, Lu CC, Chen CM, You LR, Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene Expr Patterns. 2011 Oct;11(7):384-94
1	J:211220 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A, Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 2013 Dec;41(22):10199-214
1	J:191306 Yang Y, Garcia-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G, Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 2012 Sep 13;120(11):2340-8